J Exp Med. To investigate this, we attempted to block IL secretion in chronic progressive MS using mAb directed against cell surface structures known to be involved in T cell interaction with APCs. Patients had not received immunosuppressive therapy in the past or steroid treatment in the 6 months before blood drawing. Presumably this explains why the level of CD40 ligand expression by T cells was higher in these studies than in our studies. I wish to thank everybody who contributed to my education — for their approach, understanding and for helping me to advance. Author information Article notes Copyright and License information Disclaimer. J Neuroimmunol. Our results demonstrate that functional immune abnormalities in the blood of MS patients are linked to CD40—CD40 ligand interactions and are related to disease progression. These immune abnormalities are seen most prominently in patients with the progressive form of the disease, suggesting an important link to disease pathogenesis and progression. I am very glad that a college focusing on topics of this type is located in my city district and that I had the opportunity to study there.
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In addition to progressive MS, we also studied patients with relapsing—remitting disease. I am very glad that a college focusing on topics of this type is located in my city district and that I had the opportunity to study there.
Received Apr 22; Accepted Nov 7.
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Clinically, a classic feature of MS is a course that initially involves relapses followed by remission of disease 9. Cell Separation.
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I don't regret in the least that I selected this school. Activated T cells were also studied for CD40 ligand expression by flow cytometry after h incubation and at various other times for kinetic studies.
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Search form Search. The percentage of T cells that expressed CD40 ligand was determined at various time points after activation.